Research Article

Differential Regulation of Inflammation and Immunity in Mild and Severe Experimental Asthma

Figure 1

Time schedule of the mild and severe allergic asthma mouse models. Mild model (white): male BALB/c mice were sensitized intraperitoneally with alum-precipitated OVA or saline only on days 0 and 7 and challenged with OVA or saline aerosol on days 35, 38, and 41; mice were sacrificed on day 42. Severe model (grey): male BALB/c mice were sensitized intraperitoneally with alum-precipitated TNP-OVA or saline only on days 0 and 7 and challenged intranasally with TNP-OVA/IgE immune complex or saline from day 14 up to and including day 20; mice were sacrificed on day 21.
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