TY - JOUR A2 - Lipnik-Stangelj, Metoda AU - Světlík, Svatopluk AU - Hronová, Karolína AU - Bakhouche, Hana AU - Matoušková, Olga AU - Slanař, Ondřej PY - 2013 DA - 2013/05/20 TI - Pharmacogenetics of Chronic Pain and Its Treatment SP - 864319 VL - 2013 AB - This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers. SN - 0962-9351 UR - https://doi.org/10.1155/2013/864319 DO - 10.1155/2013/864319 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -