| | Enzymes | Important gene variants | Influenced drug group | Proven effect on PK or efficacy/safety in clinical trials | References |
| | CYP2D6 | CYP2D6*1-wt
CYP2D6*3
2549A>del
CYP2D6*4
1846G>A
CYP2D6*5
CYP2D6*6
1707T>del
MxN
CYP2D6*10 | TCA
Opioids
SSRI | Opioids (codeine, tramadol, hydrocodone, and oxycodone), TCA (amitriptyline, nortriptyline, imipramine, and desipramine), and SSRI (fluoxetine, paroxetine, and citalopram) | [47, 48] |
| | CYP2C9 | CYP2C9*1-wt
CYP2C9*2 (Cys144Arg)
CYP2C9*3 (Leu359Iso)
CYP2C9*5 | NSAIDs
SSRIs
SNRIs | Coxibs (celecoxib) | [48–50] |
| | CYP2C19 | CYP2C19*1-wt
CYP2C19*2
CYP2C19*3
CYP2C19*17-Ums | NSAID
Antidepressants | SSRI (citalopram) | [48, 51, 52] |
| | CYP2C8 | CYP2C8*1-wt
CYP2C8*2 (Ile269Phe)
CYP2C8*3 (Arg139Lys, Lys399Arg) | NSAID | NSAID (ibuprofen and diclofenac) | [48, 53–55] |
| | CYP3A4 | CYP3A4*1 (2023G>A)
CYP3A4*2
CYP3A4*10
CYP3A4*17 | Opioids | Opioids (methadone and fentanyl) | [48, 56–58] |
| | UGT1A6 | UGT1A6*1
UGT1A6*2 | NSAIDs, anticonvulsants | NSAID (acetylsalicylic acid) | [59, 60] |
| | UGT2B7 | UGT2B7*2 (802C>T, H268Y),
161C>T | NSAID
Opioids
Anticonvulsants | Opioids (morphine) and anticonvulsants (lamotrigine and valproic acid) | [61–65] |
| | UGT1A1 | UGT1A1*28 | Paracetamol
Opioids | Paracetamol | [62, 66] |
| | SULT1A1 | SULT1A1*2 (G638A; Arg213His)
SULT1A1*3 (A667; Met223Val) | Paracetamol | Paracetamol | [67] |
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