Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

Figure 6

Each neural stimulation establishes a regional gate of immune cells in the CNS. Gravity or electric stimulations to soleus muscles can open the L5 gateway via regional neural stimulations-mediated chemokine expression, electronic stimulation of the quadriceps followed by neural stimulation establishes the L3 gateway, and gateways in the fifth cervical to fifth thoracic cord vessels were created by electric stimulations to triceps brachii. Therefore, it is reasonable that neural stimulations induced by stresses like social and mental ones might establish gates in some specific sites of the brain.