Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats
Figure 1
The number of offspring in groups. To induce the pregnancy loss with LPS, 160 μg kg−1 LPS (Escherichia coli 0111:B4) was administered intravenously via the tail vein on day 10 of pregnancy in LPS group. Azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy in azithromycin and azithromycin + LPS groups. Blood samples were obtained from the tail vein on day 10 of the experiment and all animals were followed during pregnancy. Animals that did and did not give birth were determined. Different letters are statistically significant ().
