Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN- and ALOX15
Figure 1
IFN- expression in the skin maintained at a relatively high level during the resolution stage of PMA-induced inflammation. PMA was painted to the dorsal skin of mice ( per group) for 3 times (twice a week) and then stopped for the resolution of inflammation. Mice were sacrificed 3 hours, 4 days, or 7 days after the third PMA treatment. The skins were removed, weighted, and homogenized in ice-cold Tris-EDTA buffer. The concentrations of IFN- (a), IL-6 (b), TNF- (c), or MCP-1 (d) in tissue supernatants were then detected at the indicated times. , compared to the level of 3 hours after the 3rd PMA treatment.
