Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN- and ALOX15
Figure 3
Neutralization of endogenous IFN- decreased the infiltration of inflammatory cells and the production of inflammatory cytokines in the skin. Mice were sacrificed 3 hours, 4 days, or 7 days after the third PMA treatment. (a) Skin sections were stained with anti-CD11b, anti-Gr1, or anti-FSP1 (red). Nucleoli were stained with DAPI (blue). Scale Bar, 50 μm. (b) The expression levels of IL-6, TNF-, MCP-1, IL-1, and IL-1 of the skin from control group or anti-IFN- group were detected at indicated time points. , compared to control group.