Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN- and ALOX15
Figure 4
Neutralization of endogenous IFN- promoted the ALOX15 expression of the skin. Mice from control or anti-IFN- group were sacrificed 4 days after the third PMA painting. The skin was removed, and the mRNA level of COX2 (a), ALOX12 (b), and ALOX15 (c) was detected by real-time PCR. (d) IFN-R knockout (KO) and wild-type 129/Sv/Ev (WT) mice were sacrificed 3 hours or 7 days after the third PMA treatment. The mRNA level of ALOX15 in the skin was measured by real-time PCR. (e) The levels of LXA4 in skin of control and anti-IFN- groups 4 days after 3 times PMA treatment were detected by ELISA. .
