Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia

<table>Nitration of tyrosine residues modulates glutamate transmission in the spinal cord. NMDAR activation increases intracellular calcium influx and leads to the production of peroxynitrite which in turn contributes to the hyperalgesic state by nitrating and subsequently activating NMDAR subunits while inhibiting GLT-1 and GS. Removal of PN by antioxidant abolished NMDA-mediated hyperalgesia by preventing tyrosine residues nitration of the glutamate pathway.</table>

Mediators of Inflammation

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Figure 7

Figure 7: Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia 

Figure 7 | Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia 