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Mediators of Inflammation
Volume 2013 (2013), Article ID 967067, 8 pages
http://dx.doi.org/10.1155/2013/967067
Clinical Study

Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters

1Unidad de Medicina Experimental, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, Mexico
2Laboratorio de Hígado, Páncreas y Motilidad, Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, Mexico
3Departamento de Biología de la Reproducción y Clínica de Desórdenes de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, México D. F. 09340, Mexico
4Servicio de Medicina Interna, Hospital General de México, México D. F. 06726, Mexico
5Servicio de Banco de Sangre, Hospital General de México, México D. F. 06726, Mexico
6Fundación Mexicana para la Salud, México D. F. 14610, Mexico
7Servicio de Cirugía General, Hospital General de México “Dr. Eduardo Liceaga”, México, 06726 DF, Mexico
8Unidad de Desarrollo Biomédico, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Ensenada 22860, Baja California, Mexico

Received 6 November 2012; Revised 8 January 2013; Accepted 9 January 2013

Academic Editor: Peter Plomgaard

Copyright © 2013 K. Suárez-Álvarez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index ( ), serum IL-12 exhibited a significant relationship with abdominal obesity ( ), body fat percentage ( ), serum glucose ( ), triglyceride ( ), and TNF-α ( ). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.