Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters

Table 1

Anthropometric and biochemical characteristics of the study subjects.

	BMI			P value
	18.5–24.9^a	25–29.9^b	≥30^c
Gender (W/M)	26/17	30/31	21/22	N. S.
Age (years)	30.3±10.3	32.4±10.2	34.7±10.8	N. S.
BMI (kg/m^2)	22.7±1.8	27.4±1.2	33.6±3.4	^b,c𝑃<0.0001
Waist circumference (cm)	80.1±6.9	91.2±6.8	107.2±9.7	^b,c𝑃<0.0001
Body fat percentage	24.2±8.1	30.3±6.1	37.5±6.9	^b𝑃<0.05, ^c𝑃<0.0001
Fasting blood glucose (mg/dL)	78.9±5.2	88.7±3.6	106.1±7.4	^b𝑃<0.05, ^c𝑃<0.0001
Fasting blood insulin (mU/L)	12.23±2.65	15.30±7.94	16.84±8.20	N. S.
HOMA-IR	2.58±0.51	3.24±0.36	3.81±0.59	^c𝑃<0.05
Total cholesterol (mg/dL)	187.2±7.6	195.8±6.9	203.5±8.1	^c𝑃<0.05
Total triglyceride (mg/dL)	136.5±9.4	172.3±11.8	251.3±19.5	^b,c𝑃<0.0001
TNF-𝛼 (ng/mL)	256±16.6	289.7±37.5	341.2±45.5	^b𝑃<0.05, ^c𝑃<0.0001
Leptin (ng/mL)	558.1±43.5	545.5±58.8	1246.3±149.6	^c𝑃<0.0001

W: women; M: men; BMI: body mass index; HOMA-IR: homeostatic model assessment-insulin resistance; TNF-𝛼: tumor necrosis factor-alpha.
Data are presented as mean ± standard deviation. Differences were considered significant when P < 0.05, as comparing overweight (b) and obesity (c) groups with normal weight subjects (a).