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Mediators of Inflammation
Volume 2013, Article ID 981984, 10 pages
http://dx.doi.org/10.1155/2013/981984
Research Article

Differential Expression of Host Biomarkers in Saliva and Serum Samples from Individuals with Suspected Pulmonary Tuberculosis

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, P.O. Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa

Received 4 August 2013; Accepted 18 September 2013

Academic Editor: Yves Denizot

Copyright © 2013 Khutso G. Phalane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [26 citations]

The following is the list of published articles that have cited the current article.

  • Paulin N. Essone, Novel N. Chegou, Andre G. Loxton, Kim Stanley, Magdalena Kriel, Gian van der Spuy, Kees L. Franken, Tom H. Ottenhoff, and Gerhard Walzl, “Host Cytokine Responses Induced after Overnight Stimulation with Novel M-tuberculosis Infection Phase-Dependent Antigens Show Promise as Diagnostic Candidates for TB Disease,” Plos One, vol. 9, no. 7, 2014. View at Publisher · View at Google Scholar
  • Robert Chang, Enkhtsetseg Purev, and Winston Patrick Kuopp. 11–34, 2015. View at Publisher · View at Google Scholar
  • Paul L.A.M. Corstjens, Elisa M. Tjon Kon Fat, Claudia J. de Dood, Jolien J. van der Ploeg-van Schip, Kees L.M.C. Franken, Novel N. Chegou, Jayne S. Sutherland, Rawleigh Howe, Adane Mihret, Desta Kassa, Marieta van der Vyver, Jacob Sheehama, Felanji Simukonda, Harriet Mayanja-Kizza, Tom H.M. Ottenhoff, Gerhard Walzl, and Annemieke Geluk, “Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa,” Clinical Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Elisabetta Venturini, Giulia Remaschi, Elettra Berti, Carlotta Montagnani, Luisa Galli, Maurizio de Martino, and Elena Chiappini, “What steps do we need to take to improve diagnosis of tuberculosis in children?,” Expert Review of Anti-infective Therapy, pp. 1–16, 2015. View at Publisher · View at Google Scholar
  • Yun-Gyoung Hur, Young Ae Kang, Sun-Hee Jang, Ji Young Hong, Ahreum Kim, Sang A Lee, Youngmi Kim, and Sang-Nae Cho, “Adjunctive biomarkers for improving diagnosis of tuberculosis and monitoring therapeutic effects,” Journal of Infection, vol. 70, no. 4, pp. 346–355, 2015. View at Publisher · View at Google Scholar
  • Luke D. Jasenosky, Thomas J. Scriba, Willem A. Hanekom, and Anne E. Goldfeld, “ T cells and adaptive immunity to Mycobacterium tuberculosis in humans ,” Immunological Reviews, vol. 264, no. 1, pp. 74–87, 2015. View at Publisher · View at Google Scholar
  • Jayne S. Sutherland, Joseph Mendy, Awa Gindeh, Gerhard Walzl, Toyin Togun, Olumuyiwa Owolabi, Simon Donkor, Martin O. Ota, Elisa Tjon Kon Fat, Tom HM. Ottenhoff, Annemieke Geluk, and Paul LAM. Corstjens, “Use of lateral flow assays to determine IP-10 and CCL4 levels in pleural effusions and whole blood for TB diagnosis,” Tuberculosis, 2015. View at Publisher · View at Google Scholar
  • Jesus F. Rangel-Santiago, Guillermina J. Baay-Guzman, Marco A. Duran-Padilla, Karla A. Lopez-Bochm, Beatriz L. Garcia-Romero, Daniel D. Hernandez-Cueto, Gerardo Pantoja-Escobar, Mario I. Vega, Rogelio Hernandez-Pando, and Sara Huerta-Yepez, “A novel role of Yin-Yang-1 in pulmonary tuberculosis through the regulation of the chemokine CCL4,” Tuberculosis, 2015. View at Publisher · View at Google Scholar
  • Seema D. Shekhawat, Hemant J. Purohit, Girdhar M. Taori, Hatim F. Daginawala, and Rajpal S. Kashyap, “Evaluation of host Hsp(s) as potential biomarkers for the diagnosis of Tuberculous Meningitis,” Clinical Neurology and Neurosurgery, 2015. View at Publisher · View at Google Scholar
  • Jennifer L. Gardiner, and Christopher L. Karp, “Transformative tools for tackling tuberculosis,” Journal Of Experimental Medicine, vol. 212, no. 11, pp. 1759–1769, 2015. View at Publisher · View at Google Scholar
  • Jennifer E. Kerr, and Gena D. Tribblepp. 83–119, 2015. View at Publisher · View at Google Scholar
  • Ruschca Jacobs, Stephanus Malherbe, Kim Stanley, Novel N. Chegou, Elizna Maasdorp, Andre G. Loxton, Gian Van Der Spuy, and Gerhard Walzl, “Diagnostic potential of novel salivary host biomarkers as candidates for the immunological diagnosis of tuberculosis disease and monitoring of tuberculosis treatment response,” PLoS ONE, vol. 11, no. 8, 2016. View at Publisher · View at Google Scholar
  • Dolapo O. Awoniyi, Andrea Teuchert, Jayne S. Sutherland, Harriet Mayanja-Kizza, Rawleigh Howe, Adane Mihret, Andre G. Loxton, Jacob Sheehama, Desta Kassa, Amelia C. Crampin, Hazel M. Dockrell, Martin Kidd, Ida Rosenkrands, Annemieke Geluk, Tom HM. Ottenhoff, P.L.A.M. Corstjens, Novel N. Chegou, and Gerhard Walzl, “Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease,” Journal of Infection, 2016. View at Publisher · View at Google Scholar
  • Ruschca Jacobs, Enock Tshehla, Stephanus Malherbe, Magdalena Kriel, Andre G. Loxton, Kim Stanley, Gian van der Spuy, Gerhard Walzl, and Novel N. Chegou, “Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment,” Cytokine, vol. 81, pp. 50–56, 2016. View at Publisher · View at Google Scholar
  • Novel N Chegou, Jayne S Sutherland, Stephanus Malherbe, Amelia C Crampin, Paul L A M Corstjens, Annemieke Geluk, Harriet Mayanja-Kizza, Andre G Loxton, Gian van der Spuy, Kim Stanley, Leigh A Kotzé, Marieta van der Vyver, Ida Rosenkrands, Martin Kidd, Paul D van Helden, Hazel M Dockrell, Tom H M Ottenhoff, Stefan H E Kaufmann, and Gerhard Walzl, “Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB,” Thorax, vol. 71, no. 9, pp. 785–794, 2016. View at Publisher · View at Google Scholar
  • Sahdeo Prasad, Amit K. Tyagi, and Bharat B. Aggarwal, “Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases,” Experimental Biology And Medicine, vol. 241, no. 8, pp. 783–799, 2016. View at Publisher · View at Google Scholar
  • Ruschca Jacobs, Kim Stanley, Gerhard Walzl, Novel N. Chegou, Stephanus Malherbe, Andre G. Loxton, and Gian van der Spuy, “Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response,” Oncotarget, vol. 7, no. 36, pp. 57581–57592, 2016. View at Publisher · View at Google Scholar
  • Anna Ritah Namuganga, Novel N. Chegou, Paul Mubiri, Gerhard Walzl, and Harriet Mayanja-Kizza, “Suitability of saliva for Tuberculosis diagnosis: comparing with serum,” BMC Infectious Diseases, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Selena Ferrian, Claudia Manca, Sugnet Lubbe, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Clive M. Gray, and Dorothy Fallows, “A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis,” Plos One, vol. 12, no. 5, pp. e0176660, 2017. View at Publisher · View at Google Scholar
  • Haiqin Jiang, Jiya Sun, Yanqing Chen, Zhiming Chen, Le Wang, Wei Gao, Ying Shi, Wenyue Zhang, Youming Mei, Santosh Chokkakula, Varalakshmi Vissa, Taijiao Jiang, Aiping Wu, and Hongsheng Wang, “Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features,” Emerging Microbes & Infections, vol. 7, no. 1, 2018. View at Publisher · View at Google Scholar
  • Novel N. Chegou, Jayne S. Sutherland, Anna-Ritah Namuganga, Paul LAM Corstjens, Annemieke Geluk, Gebremedhin Gebremichael, Joseph Mendy, Stephanus Malherbe, Kim Stanley, Gian D. van der Spuy, Magdalena Kriel, Andre G. Loxton, Belinda Kriel, Felanji Simukonda, Yonas Bekele, Jacob A. Sheehama, Josefina Nelongo, Marieta van der Vyver, Atsbeha Gebrexabher, Habteyes Hailu, Maria M. Esterhuyse, Ida Rosenkrands, Claus Aagard, Martin Kidd, Desta Kassa, Adane Mihret, Rawleigh Howe, Jacqueline M. Cliff, Amelia C. Crampin, Harriet Mayanja-Kizza, Stefan H. E. Kaufmann, Hazel M. Dockrell, Tom H. M. Ottenhoff, and Gerhard Walzl, “Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Delia Goletti, Meng-Rui Lee, Jann-Yuan Wang, Nicholas Walter, and Tom H.M. Ottenhoff, “Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease,” Respirology, 2018. View at Publisher · View at Google Scholar
  • James N. Pay, and Andrew M. Shaw, “Towards salivary C-reactive protein as a viable biomarker of systemic inflammation,” Clinical Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Charles M. Manyelo, Regan S. Solomons, Candice I. Snyders, Portia M. Manngo, Hygon Mutavhatsindi, Belinda Kriel, Kim Stanley, Gerhard Walzl, and Novel N. Chegou, “Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting,” Mediators of Inflammation, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Jesús Mateos, Olivia Estévez, África González-Fernández, Luis Anibarro, Ángeles Pallarés, Rajko Reljic, José M. Gallardo, Isabel Medina, and Mónica Carrera, “High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts,” Journal of Proteomics, vol. 195, pp. 41–52, 2019. View at Publisher · View at Google Scholar
  • Oskar Olsson, Per Björkman, Marianne Jansson, Taye Tolera Balcha, Daba Mulleta, Habtamu Yeba, Christine Valfridsson, Fredric Carlsson, and Sten Skogmar, “Plasma Profiles of Inflammatory Markers Associated With Active Tuberculosis in Antiretroviral Therapy-Naive Human Immunodeficiency Virus-Positive Individuals,” Open Forum Infectious Diseases, vol. 6, no. 2, 2019. View at Publisher · View at Google Scholar