The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro
Figure 7
Mn2+-quenching of fura-2 fluorescence traces from 2 representative experiments ( in the series) showing the effects of formoterol, indacaterol (100 nM), and salbutamol (100 and 1000 nM) on the alterations in cytosolic Ca2+ concentrations following activation of the cells with either 1 μM fMLP (a) or 200 nM PAF (b). The 3 lines in each trace correspond to the control system (—) and systems treated with 100 nM of each drug (●●●●●) or 1000 nM salbutamol (xxxx); denotes the addition of either fMLP or PAF.
