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Mediators of Inflammation
Volume 2014, Article ID 105879, 10 pages
Research Article

An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages

1Laboratório de Farmacologia, Instituto Butantan, Avenida Vital Brazil 1500, 05503-900 São Paulo, SP, Brazil
2Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
3Departamento de Genética, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil
4Departamento de Fisiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil

Received 13 September 2013; Accepted 16 January 2014; Published 6 April 2014

Academic Editor: Hidde Bult

Copyright © 2014 Vanessa Moreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Salomón Huancahuire-Vega, Luis Ponce-Soto, and Sergio Marangoni, “PhTX-II a Basic Myotoxic Phospholipase A2 from Porthidium hyoprora Snake Venom, Pharmacological Characterization and Amino Acid Sequence by Mass Spectrometry,” Toxins, vol. 6, no. 11, pp. 3077–3097, 2014. View at Publisher · View at Google Scholar
  • Zhiqiang Zhang, Yongchao Fang, Qiang Wang, Yu Sun, Chuanzhi Xiong, Li Cao, Beiyue Wang, Nirong Bao, and Jianning Zhao, “Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway,” Molecular Medicine Reports, vol. 12, no. 1, pp. 1499–1505, 2015. View at Publisher · View at Google Scholar
  • Sandra M. Burin, Danilo L. Menaldo, Suely V. Sampaio, Fabiani G. Frantz, and Fabíola A. Castro, “An overview of the immune modulating effects of enzymatic toxins from snake venoms,” International Journal of Biological Macromolecules, 2017. View at Publisher · View at Google Scholar
  • Jean-Marc Cavaillon, Mervyn Singer, Catarina Teixeira, Vanessa Moreira, and José María Gutiérrez, “Venoms,” Inflammation - From Molecular and Cellular Mechanisms to the Clinic, pp. 99–128, 2017. View at Publisher · View at Google Scholar
  • Karina F. Zoccal, Giovana Z. Ferreira, Morgana K.B. Prado, Luiz G. Gardinassi, Suely V. Sampaio, and Lúcia H. Faccioli, “LTB 4 and PGE 2 modulate the release of MIP-1α and IL-1β by cells stimulated with Bothrops snake venoms,” Toxicon, 2018. View at Publisher · View at Google Scholar
  • Basavarajaiah Swethakumar, Somanathapura K. NaveenKumar, Gajanan D. Katkar, Kesturu S. Girish, and Kempaiah Kemparaju, “Inhibition of Echis carinatus venom by DNA, a promising therapeutic molecule for snakebite management,” Biochimica et Biophysica Acta (BBA) - General Subjects, 2018. View at Publisher · View at Google Scholar
  • Sanjay Varikuti, Bijay Kumar Jha, Greta Volpedo, Nathan M. Ryan, Gregory Halsey, Omar M. Hamza, Bradford S. McGwire, and Abhay R. Satoskar, “Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites,” Frontiers in Microbiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Yuanyuan Cheng, Xuechen Li, Hung-Fat Tse, and Jianhui Rong, “Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–14, 2018. View at Publisher · View at Google Scholar