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Mediators of Inflammation
Volume 2014 (2014), Article ID 128490, 9 pages
Review Article

Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

1Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China
2Institute of Stomatology, Nanjing Medical University, No. 140 Hanzhong Road, Nanjing 210029, China
3Department of Maxillofacial Surgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 232001, China

Received 29 January 2014; Revised 13 July 2014; Accepted 14 July 2014; Published 24 July 2014

Academic Editor: Tânia Silvia Fröde

Copyright © 2014 Yu-Ming Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Epidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association of the IL-17A rs2275913G A and IL-17F rs763780T C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, , %; for GA versus GG: OR = 1.12, 95% CI: 1.02–1.23, P = 0.015, %; for AA versus GG: OR = 1.71, 95% CI: 1.38–2.41, , %; for GA + AA versus GG: OR = 1.23, 95% CI: 1.13–1.34, , %; for AA versus GG + GA: OR = 1.62, 95% CI: 1.27–2.07, , %). Succeeding analysis of HWE and stratified analysis of gastric cancer and the Asian (and Chinese) population revealed similar results. The IL-17F rs763780T>C polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese) population.