Mediators of Inflammation / 2014 / Article / Tab 2

Review Article

Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Table 2

Summary of ORs and 95% CI of IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms and cancer risk.

N * A versus GGA versus GGAA versus GGGA + AA versus GGAA versus GG + GA
OR95% CIP (%)aOR95% CIP (%)aOR95% CIP (%)aOR95% CIP (%)aOR95% CIP (%)a

Total101.281.16–1.41<0.00161.11.121.02–1.230.01527.81.711.38–2.14<0.00169.61.231.13–1.34<0.0016.41.621.27–2.07<0.00181.4
HWE81.261.13–1.41<0.00166.41.151.04–1.270.00801.631.29–2.08<0.001701.231.12–1.36<0.0019.71.511.18–1.930.00178.4
Ethnicity
 Asian 91.251.14–1.37<0.00156.51.121.02–1.230.01935.61.651.32–2.05<0.00168.61.221.12–1.33<0.0014.41.551.21–1.990.00181.6
 China71.211.10–1.34<0.00156.21.191.07–1.320.00101.461.20–1.79<0.00154.31.241.13–1.37<0.00114.91.301.09–1.560.00456.6
Design
 PB41.161.01–1.320.03163.31.141.01–1.290.04101.341.02–1.760.033651.181.05–1.320.0061.11.230.96–1.590.10869.7
 HB 51.351.23–1.48<0.00101.100.87–1.390.44763.11.971.64–2.37<0.00101.281.12–1.46<0.00111.81.871.38–2.52<0.00169.2
Location
 Gastric71.261.11–1.44<0.001701.070.96–1.190.20224.21.701.26–2.300.00177.81.181.06–1.300.00101.671.18–2.360.00487
 Others31.331.19–1.49<0.00101.271.05–1.530.0136.61.811.43–2.29<0.00101.391.18–1.65<0.00101.561.27–1.91<0.0010

C versus TTC versus TTCC versus TTTC + CC versus TTCC versus TT + TC

Total71.090.91–1.300.34764.61.060.84–1.340.629701.331.02–1.750.03801.080.87–1.350.48670.31.260.96–1.650.0980
HWE40.950.81–1.100.51646.40.920.71–1.190.65057.21.150.61–2.170.66000.930.72–1.190.55755.51.180.62–2.210.6160
Ethnicity
 China 61.080.88–1.330.43970.41.060.81–1.390.67674.71.321.00–1.740.05301.080.84–1.390.55575.11.240.94–1.630.1300
Design
 PB31.291.13–1.41<0.00132.41.341.14–1.57<0.00143.41.401.01–1.960.04501.341.05–1.57<0.00145.81.290.92–1.790.1360
 HB 40.970.77–1.210.55052.20.920.69–1.220.55457.31.200.74–1.940.46600.840.72–1.230.64358.11.200.74–1.940.4560
Location
 Gastric41.291.14–1.46<0.00101.331.13–1.55<0.00121.61.401.04–1.880.02601.341.16–1.55<0.001161.300.97–1.740.0820
 Others30.910.70–1.180.47257.40.880.62–1.240.46069.21.020.50–2.080.96200.890.64–1.220.46166.71.040.51–2.130.9050

Numbers of comparisons.
aTest for heterogeneity.