Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1
Figure 1
Evaluation of ATP-induced permeabilization in peritoneal macrophages, based on ethidium bromide (EB) uptake. (a) Peritoneal macrophages from S. mansoni-infected Swiss mice (black bars) were less sensitive to ATP-induced permeabilization than those from uninfected mice (white bars). (b) Peritoneal macrophages from C57BL/6 wild type mice (hatched white bars) respond to ATP-induced permeabilization unlike those from P2X7R KO mice (hatched gray bars). ATP-induced permeabilization values represent the % of EB uptake above basal levels by F4/80 positive cells and were expressed as mean and SEM. (Swiss) and (C57BL/6) replicates using different animals. (a) and (b) differ from each other with (one-way ANOVA followed by post hoc Newman-Keuls test).
