The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease
Photomicrographs of immunostaining for IL-35 in human colon from patients with UC (a and b), patients with CD (c and d), and healthy controls (e and f). No staining was found in the control group (e and f), and IL-35 was expressed in infiltrating immune cells (morphologically resembling lymphocytes) but not in epithelial cells. The staining was mostly cytoplasmic, and red arrows depicted immunoreactive positive cells. The number of IL-35-expressing cells in inflamed colonic tissue of patients with UC was higher than in CD patients’ tissue. Original magnification: (a), (c), (e) ×200; (b), (d), (f) ×400.