Interaction with Mesenchymal Stem Cells Provokes Natural Killer Cells for Enhanced IL-12/IL-18-Induced Interferon-Gamma Secretion

Table 1

Summarized data of the MSC-mediated IFN-γ secretion of IL-12/IL-18–stimulated NK cells shown in Figure 1.

	IL-12/18 directly		IL-12/18 after 24 h
	NK92/MSC; (%)	pNK/MSC; (%)	NK92/MSC; (%)	pNK/MSC; (%)
Figure 1(a) + Figure 1(b)
20 : 1	182±68^∗∗		211±42^∗∗
10 : 1	211±91^∗∗		261±66^∗∗
5 : 1	249±75^∗∗		459±88^∗∗
1 : 1	344±37^∗∗		714±94^∗∗
Figure 1(c)
24 h	343±129^∗∗
48 h	337±102^∗∗
72 h	448±116^∗∗
Figure 1(d)	334±215^∗	216±37^∗∗	543±295^∗∗	485±166^∗∗

Values are normalized to IFN-𝛾  secretion of stimulated NK cells only set as 100%.
Values are mean ± standard deviation of three independent experiments performed in triplicates and with three different donors of MSC.
^∗∗𝑃<0.01, ^∗𝑃<0.05 significantly different from NK cells only set as 100%.