Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels
Table 1
Demographic and clinical characteristics in ACS according to rs5361 (561A>C) E-selectin polymorphism following a dominant genetic model.
561A>C E-selectin in ACS
All patients (%)
A/A (%)
A/C + C/C (%)
value
Average ± SE
Demographics
Age, years
63 ± 11.8
63.24 ± 11.729
61.13 ± 12.312
0.364
Gender male/female
226/57 (79.9/20.1)
209/51 (80.4/19.6)
17/6 (73.9/26.1)
0.307
Glucose (mg/dL)
161.626 ± 70.74
158.884 ± 67.7846
205.5 ± 136.4716
0.556
Triglycerides (mg/dL)
171.167 ± 41.4894
171.167 ± 41.4894
0 ± 0
—
Cholesterol (mg/dL)
181 ± 53.075
181 ± 53.075
0 ± 0
—
CK (IU/L)
924.71 ± 1509.328
910.45 ± 1540.689
1093.07 ± 1097.892
0.099
CK-MB (IU/L)
110.37 ± 167.070
109.93 ± 170.653
116.05 ± 114.381
0.265
Troponin T (ng/mL)
7.2212 ± 14.10267
6.7461 ± 14.30236
12.3385 ± 10.89742
0.118
Diagnosis
UA
29 (10.2)
26 (10.0)
3 (13.0)
0.427
STEMI
214 (75.6)
200 (76.9)
14 (60.9)
0.076
NSTEMI
40 (14.1)
34 (13.1)
6 (26.1)
0.86
Risk factor
Obesity
112 (39.6)
100 (38.5)
12 (52.2)
0.143
DM2
131 (39.9)
123 (47.3)
8 (34.8)
0.175
DYS
117 (41.3)
107 (41.2)
10 (43.5)
0.497
HBP
172 (60.8)
159 (61.2)
13 (56.5)
0.411
Treatment
AA
224 (79.2)
208 (80.0)
16 (69.6)
—
ACE inhibitors
147 (51.9)
136 (52.3)
11 (47.8)
—
AnA
271 (95.8)
249 (95.8)
22 (95.7)
—
ARB
33 (11.7)
31 (11.9)
2 (8.7)
—
CCB
4 (1.4)
4 (1.5)
0 (0)
—
Antiarrhythmics
5 (1.8)
4 (1.5)
1 (4.3)
—
Diuretic
66 (23.3)
60 (23.1)
5 (21.7)
—
Antilipid therapy
233 (82.3)
213 (81.9)
20 (87.0)
—
Quantitative and qualitative data were evaluated by Mann-Whitney test and exact test, respectively. CK: creatine phosphokinase; CK-MB: creatine phosphokinase MB; UA: unstable angina; STEMI: ST elevation myocardial infarction; NSTEMI: non-ST elevation myocardial infarction; DM2: type 2 diabetes mellitus; DYS: dyslipidemia; HBP: high blood pressure; AA: antithrombin agents; AnA: antiplatelet agents; ARB: angiotensin II receptor blockers; CCB: calcium channel blockers; SE: standard error.
