Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

Table 2

Areas under the curve (AUC) of synovial and serum MMP-3 as biomarkers for distinguishing high grade synovitis.

High synovitis score versus low synovitis score	AUC	𝑃	95% CI	Tradeoff value	Youden’s index	Sensitivity; %	Specificity; %
Synovial MMP-3	0.772	<0.001	0.655~0.890	44%	0.517	88.9	62.9
Serum MMP-3	0.668	0.024	0.532~0.803	190.4 ng/mL	0.412	92.6	48.6