MSH Blunts Endotoxin-Induced MuRF1 and Atrogin-1 Upregulation in Skeletal Muscle by Modulating NF-B and Akt/FoxO1 Pathway
Figure 3
Effect of αMSH treatment (100 μg/kg) on IGF-I mRNA in liver (a) and gastrocnemius muscle (b) and on IGFBP3 mRNA in liver (c) and gastrocnemius muscle (d) in control rats or in rats treated with LPS (250 μg/kg). PF pair-fed rats. Liver IGF-I mRNA was decreased by LPS administration in both groups of rats treated with either αMSH or saline . LPS treatment decreased liver IGFBP3 mRNA , but it increased muscle IGFBP3 mRNA . αMSH treatment prevented the effect of LPS on muscle IGFBP3 mRNA, whereas it attenuated the inhibitory effect of LPS on liver IGFBP3 mRNA. Pair-feeding the rats did not modify IGF-I or IGFBP3 levels. Data are expressed as mean SEM for 8–10 rats per group. ** and *, LSD multiple comparisons test.
