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Mediators of Inflammation
Volume 2014, Article ID 192790, 11 pages
Review Article

Synthetic Phage for Tissue Regeneration

1Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626-870, Republic of Korea
2Department of Bioengineering, University of California, Berkeley, and Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

Received 27 December 2013; Accepted 18 March 2014; Published 27 May 2014

Academic Editor: Ryu-Ichiro Hata

Copyright © 2014 So Young Yoo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Controlling structural organization and signaling motif display is of great importance to design the functional tissue regenerating materials. Synthetic phage, genetically engineered M13 bacteriophage has been recently introduced as novel tissue regeneration materials to display a high density of cell-signaling peptides on their major coat proteins for tissue regeneration purposes. Structural advantages of their long-rod shape and monodispersity can be taken together to construct nanofibrous scaffolds which support cell proliferation and differentiation as well as direct orientation of their growth in two or three dimensions. This review demonstrated how functional synthetic phage is designed and subsequently utilized for tissue regeneration that offers potential cell therapy.