Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease

Figure 3

FICZ and ITE inhibit IFN-γ and IL-17 but induce IL-22 expression by CD4⁺T cells from BD patients and normal controls. Purified CD4⁺T cells from active BD patients (𝑛=6) and normal controls (𝑛=6) were stimulated with anti-CD3/CD28 and rIL-23 in the presence or absence of FICZ (100 nmol/L) or ITE (100 nmol/L) for 6 days. IFN-γ (a and d), IL-17 (b and e), and IL-22 (c and f) production in the supernatants were determined by ELISA. Paired-sample t test or Wilcoxon’s matched-pairs test for related samples and Independent-Sample t test for independent samples were used for statistical analyses. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.

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