Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis

<table><i>Histological and immunohistochemical evaluation of joints after 15 days of treatment. </i>Nonarthritic control (a), vehicle-treated (b), and gambogic acid in the early treated group (c) AIA rats (magnification of 50x and 100x in histological images and a magnification of 200x in immunohistochemical images). Notice that gambogic acid has completely prevented immune cellular infiltration and proliferation, as well as bone invasion. Bars: 100 <i>μ</i>m.</table>

Mediators of Inflammation

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Figure 5

Figure 5: Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis 