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Mediators of Inflammation
Volume 2014 (2014), Article ID 243713, 21 pages
Review Article

Interferons and Interferon Regulatory Factors in Malaria

1Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648
2Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228

Received 19 April 2014; Accepted 18 June 2014; Published 15 July 2014

Academic Editor: José C. Rosa Neto

Copyright © 2014 Sin Yee Gun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of complex origins which could be induced by uncontrolled immune responses. Major players of the innate and adaptive responses are interferons. Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies.