Mediators of Inflammation / 2014 / Article / Tab 3

Review Article

Interferons and Interferon Regulatory Factors in Malaria

Table 3

Association of TLRs and adaptor molecules gene polymorphisms with susceptibility to malaria or pathology in human.

TLRs/
adaptors
SNPsAssociationRegionRef.

TLR1S248N
rs4833095
Placental malaria and anemiaGhana[113]
I602SSusceptibility to malaria infectionAmazon[114]

TLR2 22No association with serum cytokines (TNF, IFN- , IL-1 , IL-6, IL-10) levelsUganda [115]
Susceptibility to cerebral malaria
No association with serum cytokines (TNF, IFN- , IL-1 , IL-6, IL-10) levels
No association with cerebral malaria

TLR4D299G
rs4986790
No association with susceptibility to malaria infectionBurundi, Amazon, Ghana, Iran[114, 116118]
No association with risk of placental malariaGhana [118]
Maternal anemia
Severe malaria[119]
T399INo association with mild malariaIran[116]
Severe malariaGhana[119]

TLR6S249PSusceptibility to mild malariaAmazon[114]

TLR9G1174A
rs352139
No association with susceptibility to malaria infectionBurundi[117]
Susceptibility to mild malaria Ghana [120]
Level of parasitemia
No association with serum TNF level Uganda [121]
No association with serum IFN- level in mild malaria children
Level of serum IFN- level in CM children
T1237C
rs5743836
No association with susceptibility to malaria infectionGhana, Iran[116, 118, 120]
No association with disease severityGhana[119]
No association with placental malaria[118]
Susceptibility to malaria infectionBurundi[117]
Level of parasitemiaAmazon, Ghana[114, 120]
No association with serum TNF level Uganda [121]
No association with serum IFN- level in mild malaria children
Level of serum IFN- level in CM children
T1486C
rs187084
No association with susceptibility to malaria infectionBurundi, Ghana, Iran[116118, 120]
No association with disease severityGhana[119]
No association with placental malaria[118]
No association with level of parasitemia[120]
Level of parasitemiaAmazon[114]
G2848A
rs352140
No association with level of parasitemiaGhana [120]
Susceptibility to mild malaria infection

TIRAP S180L
rs8177374
No association with susceptibility to malaria or severity of infectionBurundi, Amazon[114, 117]
Mild malaria and severe malariaGambia,
Vietnam, Kenya
[122]
Mild malariaIran[116]

CM: cerebral malaria; 22: 22 base pair deletion in the first untranslated exon; : GT dinucleotide repeat in the second intron; mild malaria: patients suffer fever with temperature greater than or equal to 38°C, malaise, muscular pain, headache, and parasite load greater than or equal to 5000 parasite/ul of blood; severe malaria: patients who suffer anaemia, prostration, respiratory distress, convulsions, and/or impaired consciousness; cerebral malaria (CM): patients who experience coma with P. falciparum on blood smear and have no other cause for coma.