Mediators of Inflammation / 2014 / Article / Tab 1

Research Article

Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases

Table 1

Baseline clinical characteristics of study cohort.

VariableCTD ()CTD-aPAH value′ value′′
Total () Mild to moderate () Severe ()

Gender
 Female (%)81.2% (95)79.2% (42)77.3% (17)80.6% (25)0.7660.765
Age (years)0.0580.921
BMI (kg/m2)0.155 0.738
FEV1% 0.010.030
DLCO%0.01 0.037
mPAP (mmHg) 0.01 0.032
sPAP (mmHg) 0.01 0.009
PCWP (mmHg) 0.385
CI (L/min/m2) 0.01 0.005
6MWD (m)0.01 0.041
WHO functional class
 I (%)76.1% (89)35.8% (19)54.5% (12)22.6% (7) 0.01 0.017
 II-III (%)23.9% (28)64.2% (34)45.5% (10)77.4% (24) 0.01 0.017
 Raynaud's phenomenon (%) 41.0% (48) 58.5% (31) 40.9% (9) 71.0% (22) 0.034 0.029
Cause of CTD
 SS29311219
 SLE42624
 MCTD221349
 RA21101
 pSS3211

value′: CTD versus total CTD-aPAH; value′′: mild to moderate CTD-aPAH versus severe CTD-aPAH. Data were presented as mean ± SD, (%).
CTD: connective tissue diseases; CTD-aPAH: connective tissue diseases-associated pulmonary arterial hypertension; BMI: body mass index; FEV1%: forced expiratory lung volume in 1s (% predicted); DLCO%: carbon monoxide diffusion capacity (% predicted); mPAP: mean pulmonary artery pressure; sPAP: systolic pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; CI: cardiac index; 6MWD: 6-minute walk test distance; SS: systemic sclerosis; SLE: systemic lupus erythematosus; MCTD: mixed connective tissue disease; RA: rheumatoid arthritis; pSS: primary Sjogren’s syndrome.