Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

Figure 3

Intranasal administration of anti-HMGB1 IgG inhibited HMGB1 expression in the lung. (a) Representative images of immunohistochemical staining for HMGB1 in lung tissue from mice in the control (A), asthma (B), control IgG-treated (C), and anti-HMGB1-treated groups (D). (b) The average optical density in the histogram represents the HMGB1 expression. The values represent the means ± standard deviations (). and compared with the asthma group.

(a)

(b)