Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

Figure 5

Intranasal administration of anti-HMGB1 reduced AHR to methacholine stimuli. The Penh values represent the OVA-induced AHR to methacholine and were measured in mice from the control, asthma, control IgG-treated, and anti-HMGB1-treated groups using a body plethysmograph. The values represent the means ± standard deviations (). and compared with the asthma group.