Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway

Figure 1

Niacin and simvastatin reduced the expressions of CD68 and NF-κB p65 in the arterial wall of guinea pigs by immunohistochemistry analysis after treatment for 8 weeks. (a) and (c) show the representative immunostained aortic sections of CD68 and NF-κB p65, respectively (20x magnification; blue = nuclei and brown = target protein). (b) and (d) show the relative levels of CD68 and NF-κB positive cells of per view field by densitometric quantitation, respectively. Data are presented as mean ± SD (𝑛=8). ^##𝑃<0.01 versus CD group; ^∗∗𝑃<0.01 versus HFD group.