MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment

Figure 1

MicroRNA-33/33* effects. MicroRNA-33/33* are transcribed from the intron of the SREBP gene. Statins and low circulating cholesterol levels promote this process. Both miRNAs also target a variety of mRNAs involved in the glucose, fatty acid, and cholesterol metabolism. In the cholesterol metabolism, their targets include molecules involved both in cholesterol transport to HDL/reverse cholesterol transport and the transport of cholesterol to bile. CH: cholesterol; all other abbreviations are explained in the text.