Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury

Figure 7

CCL3 KO animals also show a better outcome after adenine-induced TIN. (a) CD68 expression in WT and CCL3 KO animals (^∗∗∗𝑃<0.001 versus CCL3 KO group). The renal function was evaluated by serum creatinine levels (panel (b), ^∗𝑃<0.05 versus control and CCL3 KO groups) and KIM-1 transcripts levels (panel (c), ^∗𝑃<0.05 versus WT). (d) Western Blotting for p-IKK was performed in control, WT, and KO groups. (e) Protein levels of TNF-α in renal tissue (^∗𝑃<0.05 versus control and CCL3 KO groups). Fibrosis was evaluated by picrosirius staining and the graphic quantification can be observed in panel (f) (^∗𝑃<0.01 versus Control and CCL3 KO groups and ^∗∗𝑃<0.05 versus control).

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