The Inflammatory Chemokine CCL5 and Cancer Progression

Figure 1

Effects of the CCL5/CCR5 interactions in cancer. Cancer cells secrete CCL5 or induce fibroblasts to secrete CCL5 which act in a paracrine or autocrine fashion on CCR5-positive tumor cells to sustain their proliferation, to recruit immunosuppressive cells (T-reg cells, monocyte), to induce osteoclasts activation and bone metastasis, to induce neoangiogenesis, and to guide tumor cells to disseminate to distant organs.