The Inflammatory Chemokine CCL5 and Cancer Progression
Figure 3
CCL5 and CCR5 as therapeutic targets in cancer. Different strategies proposed to disrupt the CCL5/CCR5 axis. (a) CCL5/CCL5 interaction may be inhibited by CCR5 antagonists. (b) CCL5 secretion by tumor cells or by MSCs of the tumor microenvironment may be decreased by treatment with chemotherapeutic agents. (c) The interactions between tumor cells and MSCs, mediated by EGF/EGFR pair, leading to increased CCL5 secretion by MSCs, may be inhibited by the EGFR-tyrosine kinase inhibitor gefitinib.
