The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

<table>The Wnt/β-catenin pathway. In the absence of stimulus (Wnt off), β-catenin is constantly phosphorylated by CKIα and GSK3β. These phosphorylations constitute a signal for β-catenin polyubiquitination and hydrolysis by the proteasome 26S. In the presence of Wnt protein ligands (Wnt on), the destruction complex constituted by the proteins APC, Axin, CKIα, and GSK3 is inactivated and β-catenin, which is constantly synthetized, accumulates in the cytoplasm and nucleus where it interacts with TCF/LEF transcription factors to enhance expression of specific genes.</table>

Mediators of Inflammation

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Figure 1

Figure 1: The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria