Tumor Necrosis Factor-α-Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin
Figure 2
Apocynin improves TNFα-induced histological changes of the colon. (a) Histological examination of the colon sections of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip). Mice were treated as described in Figure 1(a), and colon sections were stained with hematoxylin and eosin (H&E) and analyzed by light microscopy (Gx400); (b) histological score damage in the colon of mice treated with TNFα (10 μg · kg−1, ip) in the presence or absence of apocynin (25 mg · kg−1, ip). Results from mice treated with 10 μg kg−1 TNFα were matched to control mice with Mann-Whitney’s test. Values are means ± SEM from mice in each group. and versus control group; and versus TNFα-treated group.
