Tumor Necrosis Factor-α-Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin

Table 1

TNF-induced colitis results in morphological alterations of the colon and spleen, an effect that is prevented by apocynin.

Group	Colon weight (mg)	Colon length (cm)	Spleen weight (mg)
Control	204 ± 19	8.1 ± 0.3	105 ± 10
TNF (6 hr)	311 ± 16**	7.5 ± 0.3*	133 ± 12
TNF (18 hr)	361 ± 16**	6.6 ± 0.6***	167 ± 13**
TNF (36 hr)	286 ± 22*	7.3 ± 0.2**	143 ± 13*
APO + TNF (6 hr)	261 ± 15^#	7.8 ± 0.4	116 ± 10
APO + TNF (18 hr)	226 ± 15^##	7.4 ± 0.4^#	126 ± 17^#
APO + TNF (36 hr)	211 ± 14^#	7.7 ± 0.2^#	124 ± 11

Data are expressed as means ± S.E.M from mice in each group. , , and versus control; and versus TNF.