Active Smoking Increases Microsomal PGE2-Synthase-1/PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms
Figure 3
(a) Representative immunohistochemical images of EP-4 in aorta samples from current smokers (CS, left) and noncurrent smokers (N-CS, right) patients, showing EP-4 immunostaining of MVEC (A, A′), the scarce presence of EP-4 immunostaining in media layer in areas free of leucocyte infiltration (B, B′), and EP-4 positive leukocytes (C, C′). Red arrow-ends indicate some immunostained cells. Size bars: 50 μm. (b) Correlation between mPGES-1 transcript levels and those of endothelial cell and macrophage markers and between EP-4 and mPGES-1; Pearson product moment correlation applied to log 10-transformed data ().
