Active Smoking Increases Microsomal PGE₂-Synthase-1/PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms

Table 4

Plasma levels of PGE₂ in the AAA samples stratified by cardiovascular risk factors. The number of patients in every group is indicated in Table 1. Plasma levels of PGE₂ are expressed as pg/mL.

	Median	25th–75th percentile	𝑃 value versus no-factor^a
Plasma-PGE2
No current smoking	55.9	39.3–71.1
Current smoking	68.0	57.1–119.5	0.008
No renal insufficiency	58.4	44.0–71.4
Renal insufficiency	59.4	39.3–104.3	0.786
No hypertension	70.1	53.0–95.2
Hypertension	56.2	39.4–77.2	0.140
No diabetes mellitus	56.5	38.6–94.9
Diabetes mellitus	60.7	55.8–68.8	0.294
No hyperlipidemia	55.8	44.5–101.9
Hyperlipidemia	60.7	41.2–72.0	0.947
No COPD^b	59.4	43.3–74.3
COPD	57.1	43.5–115.9	0.807

aMann-Whitney rank sum test.
^bChronic occlusive pulmonary disease.