Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models
Figure 4
ASO-mediated lowering of human CRP in CRPtg mice subjected to RCCA ligation. Serum human CRP values were determined by ELISA for rats injected i.p. with (i) the CRP targeting ASO ISIS 353512 (10 mg/kg/wk, ; 25 mg/kg/wk, ; 50 mg/kg/wk, ), (ii) the control ASO ISIS 141923 (20 mg/kg/wk, ), or (iii) an equivalent volume of 0.9% saline . The arrow indicates the day RCCA ligation surgery was performed.
