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Mediators of Inflammation
Volume 2014, Article ID 378281, 18 pages
http://dx.doi.org/10.1155/2014/378281
Review Article

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

1Department of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands
2Department of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
3Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands
4Department of Haemato-Oncology, University Hospital and Charles University Faculty of Medicine Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic
5Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
6Department of Otolaryngology and Head and Neck Surgery, City of Hope National Medical Center, City of Hope, 1500 East Duarte Road, Duarte, CA, USA
7Department of Hematology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
8Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands
9Department of Oral- and Maxillofacial Surgery, VU University Medical Center, VU University, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands

Received 19 December 2013; Accepted 27 February 2014; Published 10 April 2014

Academic Editor: Vera L. Petricevich

Copyright © 2014 T. M. Haverman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.