MicroRNA-146a Decreases High Glucose/Thrombin-Induced Endothelial Inflammation by Inhibiting NAPDH Oxidase 4 Expression
Figure 3
Nox4 was identified as a target of miR-146a. (a) Bioinformatic miR target analysis identified homology between miR-146a and the 3′-UTR of the human Nox4 mRNA, indicating potential regulation of Nox4 by miR-146a. (b) A luciferase reporter assay showed that the miR-146a mimic could downregulate relative luciferase activity of pGL2-Nox4-3′-UTR compared with the miR-control. The bars represent the means ± SEM from 6 experiments. , as compared with the miR-control.
