Research Article
Expression of Toll-Like Receptors 3, 7, and 9 in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus
Table 1
Clinical and laboratory characteristics of the study group.
| | Features | Number of patients (%)
or mean (range) | % |
| | Nunber of patients | 35 (100%) | 100% | | Age (years) |
43.6 (25–65) | | | Disease duration (years) | 7.16 (0.25–21) | | | Gender (male/female) | 5 (14.3)/30 (85.7) | 14.3/85.7 | | Active/nonactive SLE (SLAM) | 22 (62.8)/13 (37.2) | 62.8/37.2 | | SLICC/ACR-0 | 13 (37.2) | 37.2 | | SLICC/ACR-1 | 14 (40) | 40 | | SLICC/ACR-2 | 5 (14.3) | 14.3 | | SLICC/ACR-3 | 1 (2.8) | 2.8 | | SLICC/ACR-4 | 1 (2.8) | 2.8 | | SLICC/ACR-5 | 1 (2.8) | 2.8 | | Immunosuppressive therapy Y/N | 19 (54.3)/16 (45.7) | 54.3/45.7 | | Joint symptoms | 25 (71.4) | 71.4 | | Skin lesions | 34 (97.1) | 97.1 | | Reticuloendothelial system involvement | 10 (28.6) | 28.6 | | Cardiovascular symptoms | 22 (62.8) | 62.8 | | Neurological symptoms | 29 (82.8) | 82.8 | | Renal symptoms (creatinine > 1.3 mg/dL) | 1 (2.8) | 2.8 | | Anaemia (Hb < 12 g/dL) | 9 (25.7) | 25.7 | | Leucopenia (WBC < 3.5 G/L) | 9 (25.7) | 25.7 | | Lymphopenia (lymphocyte count < 1 G/L) | 15 (42.8) | 42.8 | | Low platelet count (PLT < 150 G/L) | 13 (37.1) | 37.1 | Erythrocyte sedimentation rate
(ESR > 25 mm/h) | 22 (62.8) | 62.8 | | Gammaglobulins < 12% all proteins | 8 (22.8) | 22.8 | | Antinuclear antibodies (ANA > 1/160) | 34 (97.1) | 97.1 | | The presence of anti-dsDNA antibodies | 9 (25.7) | 25.7 | | Complement C3 < 0.9 G/L | 18 (51.4) | 51.4 | | Complement C4 < 0.1 G/L | 7 (20) | 20.0 |
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SLICC/ACR: Systematic Lupus International Collaborating Clinics/American College of Rheumatology; SLAM: Systemic Lupus Activity Measure.
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