A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

Figure 2

Icariin decreases Th17 cells and represses IL-17 production in vivo. (a) Samples of spleen tissue from mice treated with icariin or control were stained for CD4⁺IL-17⁺ T cells. (b) Expression of IL-17 mRNA was determined using real-time PCR in splenocytes from mice with CIA in each group. (c) Flow cytometry analysis of the synovial CD4⁺IL-17⁺ T cell subset in mice with CIA in each group. versus all other groups, .

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