Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses
Effect of LTL in cellular localization of (a) intercellular adhesion molecule-1 (ICAM-1, green) and vascular cell adhesion molecule-1 (VACM-1, red); arrow indicates localization of cell adhesion molecule evaluated by laser scanning confocal microscope in 100x magnification. (b) Western blot protein level expression of cell adhesion; ICAM-1, VCAM-1, P-selectin, and E-selectin were markedly suppressed after E. coli O18:K1, 104 CFU challenge and pretreatment with LTL at doses LTLD1 (25 mg/kg) and LTLD2 (50 mg/kg) in mice lung.
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