TY - JOUR
A2 - Cooper, Dianne
AU - Sun, Shaomei
AU - Wu, Hongmei
AU - Zhang, Qing
AU - Wang, Chongjin
AU - Guo, Yinting
AU - Du, Huanmin
AU - Liu, Li
AU - Jia, Qiyu
AU - Wang, Xing
AU - Song, Kun
AU - Niu, Kaijun
PY - 2014
DA - 2014/04/29
TI - Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
SP - 412386
VL - 2014
AB - Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (both P for trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.
SN - 0962-9351
UR - https://doi.org/10.1155/2014/412386
DO - 10.1155/2014/412386
JF - Mediators of Inflammation
PB - Hindawi Publishing Corporation
KW -
ER -