Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

Table 4

Cohort analysis: adjusted relationships of categories of peripheral blood leukocyte counts to the incidence of the metabolic syndrome (𝑛 = 13,061)¹.

	Categories of peripheral blood leukocyte counts (range: ×1,000 cells/mm^3)								𝑃 for trend^2
	Subnormal; (1.1–3.9)	Level 2; (4.0–4.9)	Level 3; (5.0–5.9)	Level 4; (6.0–6.9)	Level 5; (7.0–7.9)	Level 6; (8.0–8.9)	Level 7; (9.0–9.9)	Above-normal; (10.0–14.5)
	(𝑛=1123)	(𝑛=3391)	(𝑛=4019)	(𝑛=2636)	(𝑛=1182)	(𝑛=442)	(𝑛=163)	(𝑛=105)
Person-years of follow-up	2575	7724	9172	5811	2654	979	394	249	—
Number with metabolic syndrome (presence of 3 of 5 risk factors)	158	662	1010	835	420	162	58	39	—
Crude	Reference	1.40 (1.18, 1.66)^3	1.79 (1.51, 2.12)	2.34 (1.97, 2.77)	2.58 (2.15, 3.09)	2.59 (2.13, 3.16)			<0.0001
Age- and sex-adjusted	Reference	1.32 (1.11, 1.58)	1.63 (1.38, 1.93)	2.07 (1.74, 2.46)	2.28 (1.90, 2.74)	2.15 (1.76, 2.63)			<0.0001
Age-, sex-, and BMI-adjusted	Reference	1.22 (1.03, 1.45)	1.36 (1.14, 1.60)	1.60 (1.34, 1.90)	1.67 (1.39, 2.02)	1.56 (1.28, 1.91)			<0.0001
Multiple adjusted^4	Reference	1.21 (1.02, 1.44)	1.35 (1.14, 1.59)	1.58 (1.33, 1.88)	1.64 (1.36, 1.98)	1.50 (1.22, 1.84)			<0.0001

1BMI: body mass index; HDL: high-density lipoprotein cholesterol.
²Analysis by Cox proportional hazards model.
³Unadjusted hazard ratios (95% confidence interval) (all such values).
⁴Adjusted for age, sex, BMI, smoking status, drinking status, and family history of cardiovascular disease, hypertension, hyperlipidemia, and diabetes.
(Metabolic syndrome was defined with AHA Scientific Statements criteria in 2009 [15].)