Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women

Table 1

Anthropometric and plasma variables of normal/overweight and obese groups.

Characteristic; 𝑁=136	Normal/overweight; (𝑛=34)	Obese I; (𝑛=33)	Obese II; (𝑛=33)	Obese III; (𝑛=36)
Age (yrs)	46.7±0.7	42.5±1.6	38.8±1.2	41.4±1.9
BMI (kg/m^2)	25.1 (22.5–27.7)	41.5 (35.5–43.2)***	48.6 (46.4–49.9)***	56.4 (53.4–63.2)***
Waist circumference (cm)	87.2±1.4	126.1±2.7^∗∗∗	141.5±1.5^∗∗∗	156.8±2.7^∗∗∗
BP systolic (mmHg)	115 (102–126)	132 (120–140)***	138 (129–146)***	139.5 (129–145)***
BP diastolic (mmHg)	70 (60–80)	83 (73–90)***	84 (77–93)***	84 (78–93)***
Glucose (mmol/L)	5.7 (5.1–6.1)	5.4 (4.6–6.0)	5.3 (4.8–5.7)	5.7 (5.0–6.8)
Total cholesterol (mmol/L)	4.9±0.1	4.8±0.2	4.9±0.2	4.9±0.1
HDL-C (mmol/L)	1.7 (1.6–2.1)	1.5 (1.3–2.3)*	1.4 (1.2–2.2)**	1.4 (1.3–2.2)*
LDL-C (mmol/L)	2.8±0.1	2.8±0.2	2.8±0.1	2.8±0.1
Triglyceride (mmol/L)	1.5 (1.0–2.5)	1.9 (1.4–3.7)	2.2 (1.5–4.4)*	2.0 (1.4–3.8)
ApoB (g/L)	1.1 (0.9–1.4)	1.1 (0.7–2.2)	1.1 (0.7–1.6)	1.1 (0.7–1.9)
ApoA1 (g/L)	1.6 (1.4–1.8)	1.4 (1.2–1.8)**	0.9 (0.7–1.9)***	1.0 (0.9–1.9)***
Adiponectin (μg/mL)	22.6 (19.1–47.0)	16.8 (7.1–32.2)**	10.5 (6.6–12.2)***	8.5 (5.4–10.5)***

136 patients were classified into four weight categories based on their BMI: normal/overweight (BMI ≤ 30; 𝑛=34), obese group I (BMI > 30 to BMI ≤ 45; 𝑛=33), obese group II (BMI > 45 to BMI ≤ 51; 𝑛=33), and obese group III (BMI > 51 to BMI ≤ 80; 𝑛=36). Values are expressed as mean ± SEM for normally distributed data and median interquartile range for nonnormally distributed data. Results were compared by one-way ANOVA versus normal/overweight group where ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001. BMI: body mass index; BP: blood pressure; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; apoB: apolipoprotein B; apoA1: apolipoprotein A1.