Expression of Genes Related to Prostaglandin Synthesis or Signaling in Human Subcutaneous and Omental Adipose Tissue: Depot Differences and Modulation by Adipogenesis

Table 2

Pearson correlation coefficients between PLA2G16, AKR1B1, PTGDS, PTGER3, or PTGER4 mRNA expression level in subcutaneous (SC) or omental (OM) adipose tissue and body composition or fat distribution ( = 46).

Variables	PLA2G16		AKR1B1		PTGDS		PTGER3		PTGER4
	OM	SC	OM	SC	OM	SC	OM	SC	OM	SC
Body composition
Total body fat mass^a	—	—	—	0.39^*	0.26^†	—	—	0.26^†	0.27^†	0.47^**
Lean body mass^a	—	—	0.31^*	0.38^*	—	—	—	—	—	0.36^*
Adipose tissue areas
Total^c	0.31^*	—	—	0.35^*	—	—	0.35^*	—	0.41^*	0.51^**
Visceral^a	—	—	0.26^†	0.41^*	0.43^*	—	0.43^*	—	0.38^*	0.48^**
Subcutaneous^c	0.24^†	—	—	0.31^*	—	—	—	—	0.31^*	0.52^**
Adipocyte diameter
Omental^b	0.31^*	—	—	0.47^**	0.25^†	—	0.51^**	—	0.33^*	0.54^**
Subcutaneous^a	0.30^*	—	—	0.37^*	—	—	0.35^*	—	—	0.35^*

PLA2G16: phospholipase A2, AKR1B1: PGF synthase, PTGDS: PGD synthase, PTGER3: PGE receptor, and PTGER4: PGE receptor. Expression levels relative to ATP5O mRNA expression.
^a = 45, ^b = 44, ^c = 43, ^** ≤ 0.001, ^* ≤ 0.05, ^† ≤ 0.10, and (—): no significant association.